1810 January 0
Bank of Pittsburgh, second in the borough and first with local capital, was organized and operated for a time under the name of Pittsburgh Manufacturing Company.

1810 January 0
Population: 4786; Allegheny County, 25,317.

1810 November 9
The city was inundated by a flood of 35.2 feet.

1811 January 0
The Reverend Francis Herron began a 49-year pastorate in the First Presbyterian Church.

1811 May 31
The Vigilant Fire Company was organized.

1811 June 24
First Masonic Hall dedicated.

1811 August 0
Old St. Patrick's Church, the city's first Roman Catholic church, was dedicated at Liberty and Washington streets.

1811 October 25
The New Orleans, which was built at a cost of $40,000 by Nicholas Roosevelt, sailed down the Ohio to establish the first regular packet service between Natchez and New Orleans and thus became the first steamboat to navigate western rivers.

1812 January 0
The first rolling mill was built by Christopher Cowan.

1812 January 0
Rigging for Oliver H. Perry's fleet on Lake Erie was made in the borough. Steam-engine works, built by Oliver Evans and managed by Mark Stackhouse, went into operation in May.

1812 January 0
Christopher Cowan built a steam mill for slitting iron.

1812 January 0
Elliott Nursery was established at Smithfield Street.

1812 May 7
William Turner and Company opened what is believed to have been the city's first theater.

1812 September 10
The Pittsburgh Blues, a military unit, left on a year's expedition in the Ohio Country, in the service of the United States.

1813 January 0
The Comet, a stern-wheel steamboat, was built.