1800 January 0
Zadok Cramer, a New Jersey printer, purchased Gilkinson's Book Store, renamed it the Sign of the Franklin Head, began a printing and book-binding business, and printed his first Almanack.

1800 January 0
Pittsburgh commercial life revolved around 63 shops, 23 of them general stores, six shoe shops, four bakeries, and four hat shops.

1800 January 0
Population: 1565; Allegheny County, 15,087.

1800 January 0
Perkins store, first "department store" west of Philadelphia, was opened.

1800 August 16
The city's second news-paper, Tree of Liberty, was published by John Israel, with Hugh Henry Brackenridge as chief backer and chief editorial writer.

1801 November 24
The associate Presbyterian Church was organized. Zadok Cramer printed the first edition of the Navigator. a guide to river navigation.

1802 January 0
Jeffery Scaife Tin and Japanned Ware Manufactory, parent organization of the William B. Scaife & Sons Company began business in the Diamond.

1802 January 0
Pittsburgh Almanack stated that industry in Pittsburgh included one large brewery, two glassworks, one fine-glass factory, one large paper mill, several oil mills, powder works, ironworks, saltworks, saw - and grist - mills, and a boat yard.

1802 August 9
The Borough Council ordered four public wells to be sunk on Market Street -- the beginning of Pittsburgh's water system.

1803 January 0
The Pittsburgh Almanack for the Year 1803 estimated the total value of Pittsburgh manufacturing at $358,903. Of that amount, iron manufacturing accounted for $56,548 from the production of 180 tons of castings and bar iron and 40 tons of nails. Textile manufacturing was second in value with $46,825.

1803 January 0
The rivers were beginning to be used for the shipment of coal from Pittsburgh to Philadelphia via New Orleans.

1803 January 26
In the first theatrical production in the city, the Bromly and Arnold traveling troupe of actors presented a tragedy, The gamester, at the courthouse.

1803 March 26
A public meeting was held to consider a proposal for a bank in the borough.

1804 January 0
A newly established stagecoach line was offering "speedy" six-day service between Pittsburgh and Philadelphia. Peter Eltonhead, an Englishman, founded the first large-scale cotton mill.

1804 January 0
General Presley Neville, burgess of Pittsburgh, asked George Stevenson, president of the Council, to study smoke problems and, in particular, the possibility of higher chimneys as a smoke-control measure. His letter stated that "not only the comfort, health and, in some measure, the con-sequence of the place, but the harmony of the inhabitants, depends upon speedy measures being adopted to remedy this nuisance."