1717 January 0
Michael Bezallion, Pennsylvania fur trader, passed the future site of Pittsburgh en route from the Illinois country to Philadelphia, where he made a report of the trip.

1717 January 0
White traders began to establish trading posts in the territory of the Ohio, Allegheny, and Monongahela valleys. The largest settlement was Logstown (now Ambridge), about four miles north of the fork of the Ohio.

1748 January 0
Conrad Weiser (1696-1760), the German, who for thirty years was prominent in Pennsylvania's negotiations with the Indians, was the guest of the Delaware Indian Chief Shannopin at the mouth of Two Mile Run (the present Lawrenceville section of Pittsburgh).

1749 August 7
Celoron de Blainville (1693-1759), with 43 French soldiers, 180 Canadians, and a band of Indians, floated past the site of Pittsburgh, once more claiming possession of the Ohio Valley for King Louis XV of France. Chaplain Father Bonnecamps kept a journal and made a map of the trip.